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  • 08
    11

    2015

    Scientists Image Peptide-Binding GPCR Activity for First Time

    Researchers at the National Institutes of Health say they used atomic level images to show how the neuropeptide hormone neurotensin might activate its receptors. Their description reportedly is the first of its kind for a neuropeptide-binding G protein-coupled receptor (GPCR), a class of molecules involved in a wide range of disorders and the target of many drugs.

  • 08
    11

    2015

    3D Scaffold System May Lead to Novel Anticancer Therapies

    Scientists at Rice University and University of Texas MD Anderson Cancer Center have developed a way to mimic the conditions under which cancer tumors grow in bones. By placing cancer cells in a three-dimensional scaffold and subjecting them to the forces that push, pull, and continually flow through the body, the researchers are better able to test the efficiency of cancer-fighting drugs.

  • 08
    10

    2015

    Urine Proteins Point to Early-Stage Pancreatic Cancer

    Raising hopes for a simple, noninvasive, inexpensive, and easily repeatable test for pancreatic cancer, scientists at Barts Cancer Institute, Queen Mary University, have developed a three-protein biomarker panel that can screen urine samples to identify pancreatic cancer when it is still in its early stages.

  • 08
    10

    2015

    Researchers Provide Critical New Insights on DNA Repair

    Researchers at the University of Texas MD Anderson Cancer Center say they have gained new insights on the role of fumarase in DNA repair. They published their study (“Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation”) in Nature Cell Biology.

  • 08
    07

    2015

    Purification of Recombinant AAV Vectors for Preclinical Applications

    Cesium chloride- and iodixanol-based density gradients represent the core step in most protocols for serotype-independent adeno-associated virus (AAV) purification.