Animal Models for Anxiety and Depression
저자: 업로드:2017-08-25 조회수:
Stress, anxiety and depression are closely related to the
phenomenon, most of the anxiety and depression patients have experienced
severe psychological stress events. Thus, stress events are seen as a
cause of anxiety and depression, or at least on genetic basis, which can
lead to the generation of emotional disorders. Anxiety and Depression
Animal models place animals in a series of stress situations (latent or
actual threats, acute or chronic) that cause emotional disorders and
then apply specific measures to behavioral and physiological indicators
Detection, and thus explore the mechanisms of this emotional disorder,
as well as the identification and screening of anxiolytics or
antidepressants.
Anxiety Animal Model: Anxiety is a
pre-known but inevitable, upcoming stress events caused by an expected
response to fear, fear, tension and other psychiatric symptoms as the
main performance, accompanied by palpitations, sweating, cold hands and
feet and other plant neurological disorders, the core symptoms of
concern.
In order to prove whether the anxiety
model stimulates the animal's anxiety response should be looking for
ways to measure the anxiety response and indicators; the animal's
anxiety response is usually measured using animal behavior or
physiological responses to stress or new heterosexual events. These
disgusting situations of the animal include open spaces, bright or have a
certain height, all of which form the basis for the use of inquiry
tests to measure animal anxiety reactions.
The main behavioral indicators include: (1) the inhibition of
exploratory behavior, the number of animals to explore the open arm
decreased, the time to stay in the open arm to reduce the number of
lattice reduction, animals to avoid the bright place; (2) social
behavior reduction, mutual sniffing, (3) mutual chase the behavior was
significantly reduced, the animals tend to escape other animals.
Depression Animal model: depression shows a depression, slow
thinking, and slow behavior as the main symptoms of mental illness, and
may be accompanied by reduced sleep, weight and other physical symptoms,
uncontrollable stress is an important reason for its production. Thus,
the common characteristic of all depressive animal models is that
depressive behavior is caused by uncontrollable negative events. At
present, the establishment of depression animal models is divided into
three categories: behavioral despair, acquired helplessness and chronic
mild unpredictable stress.
Medicilon's Pharmacology
department functions in accordance with the needs of our customers for a
variety of effective animal models used to detect drug effectiveness.
We offer non-human primates, dogs, mice and rats, rabbits, guinea pigs
and others in our services. At present, we have various proven
effective animal models. Furthermore, our experienced staffs operate
with strong theoretical basis. We offer the services which are flexible
for custom development of various types of models to meet the
requirements of our clients.
Recently, Medicilon
appointment Dr. Dong Wenxin as the company's senior director of
pharmacology team. Dr. Dong has long been engaged in pharmacological
research, mainly related to depression, Alzheimer's disease, pain,
anxiety, Parkinson's disease and other fields.
We believe
that the addition of Dr. Dong will greatly contribute to the business
development and strategic planning of the Medicilon pharmacological
team, to further expand the Medic
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