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Psoriasis in Mice Improved by Fire Ant Venom Toxin

저자:   업로드:2017-09-13  조회수:

    Scientists in the US have discovered a potential new treatment for psoriasis in humans. Using the compounds derived from solenopsin, the toxic constituent of fire ant venom, they were successfully able to reduce skin thickening and inflammation in a mouse model of psoriasis.


    Psoriasis is an autoimmune chronic inflammatory skin condition that affects an estimated 2.5-6 million patients in the U.S., or about 1-2% of the population. Topical treatments, primarily corticosteroids, have been the mainstay of managing mild to moderate psoriasis for 50 years. Systemic drugs including methotrexate, vitamin A derivatives, and cyclosporine, and biologic treatments including drugs that target tumor necrosis factor alpha (TNF-alpha), interleukin (L)-23, and IL-17, are used to treat more generalized and severe disease.


    Biologic therapies aren’t suitable for most patients with mild to moderate disease. They are expensive, and can also result in systemic immunosuppression. Unfortunately, long-term use of topical steroids can also lead to resistance, and may cause cutaneous atrophy. Some thicker lesions are also refractory to topical steroid therapy, report Jack L. Arbiser, M.D., Ph.D., professor of dermatology at Emory University School of Medicine, his colleagues at Emory, and colleagues at the Veterans Affairs Medical Center (Decatur, GA), Case Western Research University (Cleveland, OH), the University of Alabama (Birmingham, AL), and Universität München (Germany). Alternative topical treatments, including vitamin D analogs, retinoids, and calcineurin inhibitors, have been developed, but these haven’t really impacted topical steroid use, the researchers suggest.




    Ceramides are a family of lipids that play a key role in maintaining skin-barrier function, and loss of this barrier function leads to increased expression of vascular endothelial growth factor (VEGF), which is a major mediator of angiogenesis and inflammation. The use of emollients that restore the skin barrier can help to resolve psoriasis, but they also can’t cure the disease. Unfortunately, ceramides can also act as what the researchers call a "double-edged sword." While in their natural state they promote skin homeostasis, ceramides can be metabolized to sphingosine-1-phosphate (S1P), which is linked with cellular growth, inflammation, and tumorigenesis.


    Dr. Arbiser’s laboratory had previously shown that the fire ant venom compound solenopsin inhibits blood vessel growth and offers potential as an anticancer agent. In their latest work, reported in Scientific Reports (“Evidence for biochemical barrier restoration: Topical solenopsin analogs improved inflammation and acanthosis in the KC-Tie2 mouse model of psoriasis,”) the researchers describe the development of two solenopsin-derived analogs that remain in their

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