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저자:medicilon 업로드:2021-02-10 조회수:
Inflammatory immune diseases have gained much attention as the incidence has grown bigger each year. The diseases can affect many parts of human bodies and reduce the quality of life drastically. Yet the diagnoses can be frustrating and stressful because no one is sure what causes such diseases.
The preclinical pharmacology department of Medicilon has been deeply involved in this field for many years, and has provided a variety of stable and reliable animal models for different targets and pathways for the evaluation of inflammatory immune disease treatments in order for the successful clinical transformation.
RA is a chronic and systemic inflammatory autoimmune disease mainly targeting joints. It has a very high disability rate. The cause of the disease is still unclear.
Medicilon models that you can choose from:
Major Endpoints:
Foot Volume
△CIA Models & △CFA Models
Arthritis Index
△CIA Models
Cytokine Expression
△CFA Models
Other arthritis models:
Psoriasis is a common skin disease that occurs worldwide. It is a disease that is not only closely related to genetics, but also obviously related to the environment.
Medicilon establishes diverse models that captures key features of psoriasis, including:
Major Endpoints:
Skin thickness
△Pathological skin change of Imiquimod induced psoriasis mice
Ear thickness
△Pathological skin change of IL-23 induced psoriasis mice
Skin colligation score of mice
△Pathological skin change of Imiquimod induced psoriasis mice
Pathological skin score
△Imiquimod induced psoriasis & △IL-23 induced psoriasis
Atopic dermatitis is a chronic, recurring, inflammatory skin disease, often accompanied by other symptoms such as allergic rhinitis, asthma, eczema, etc. The cause of the disease is not yet clear and there is no cure.
The disease related models include:
Skin score
△DNFB induced chronic dermatitis
Skin thickness
△DNFB induced chronic dermatitis
Inflammatory bowel disease (IBD) is a group of unexplained chronic intestinal inflammatory diseases. Due to the increasing incidence, it has become a common digestive system disease in our country. It mainly refers to ulcerative colitis and Crohn's Disease.
Our IBD models includes:
△Colon length of TNBS induced IBD rats models
△Colon weight of DSS induced IBD mice models