Medicilon’s pharmacology models for inflammatory-immune diseases

저자：medicilon   업로드：2021-02-10  조회수：

Inflammatory immune diseases have gained much attention as the incidence has grown bigger each year. The diseases can affect many parts of human bodies and reduce the quality of life drastically. Yet the diagnoses can be frustrating and stressful because no one is sure what causes such diseases.

The preclinical pharmacology department of Medicilon has been deeply involved in this field for many years, and has provided a variety of stable and reliable animal models for different targets and pathways for the evaluation of inflammatory immune disease treatments in order for the successful clinical transformation.

RA is a chronic and systemic inflammatory autoimmune disease mainly targeting joints. It has a very high disability rate. The cause of the disease is still unclear.

Medicilon models that you can choose from:

• CIA mice/rats Models
• CFA rats Models

Major Endpoints：

Foot Volume

△CIA Models & △CFA Models

Arthritis Index

△CIA Models

Cytokine Expression

△CFA Models

Other arthritis models:

• Carrageenan-induced acute arthritis mice/rats models
• Uric acid sodium induced gouty arthritis rats models

Psoriasis is a common skin disease that occurs worldwide. It is a disease that is not only closely related to genetics, but also obviously related to the environment.

Medicilon establishes diverse models that captures key features of psoriasis, including:

• △ IL-23 induced hyperplasia of auricle epidermis mice models
• △ Imiquimod induced psoriasis mice models
• △ Vaginal epithelial mitosis mice models
• △ Tale exfoliation mice models

Major Endpoints:

Skin thickness

△Pathological skin change of Imiquimod induced psoriasis mice

Ear thickness

△Pathological skin change of IL-23 induced psoriasis mice

Skin colligation score of mice

△Pathological skin change of Imiquimod induced psoriasis mice

Pathological skin score

△Imiquimod induced psoriasis & △IL-23 induced psoriasis

Atopic dermatitis is a chronic, recurring, inflammatory skin disease, often accompanied by other symptoms such as allergic rhinitis, asthma, eczema, etc. The cause of the disease is not yet clear and there is no cure.

The disease related models include:

• △ DNFB induced chronic dermatitis mice models
• △ DNFB & OX induced chronic dermatitis mice models
• △ Phorbol ester induced acute eczema mice models
• △ DNFB induced acute eczema mice models

Skin score

△DNFB induced chronic dermatitis

Skin thickness

△DNFB induced chronic dermatitis

Inflammatory bowel disease (IBD) is a group of unexplained chronic intestinal inflammatory diseases. Due to the increasing incidence, it has become a common digestive system disease in our country. It mainly refers to ulcerative colitis and Crohn's Disease.

Our IBD models includes:

• TNBS induced IBD rats models
• DSS induced IBD mice models

△Colon length of TNBS induced IBD rats models

△Colon weight of DSS induced IBD mice models

이전：Medicilon assists Livzon to obtain the clinical approval of novel coronavirus vaccine

다음에：Medicilon’s Top 10 Greatest Achievements in 2020