Common Antiseptic Ingredients Impair Hormone Response

저자：   업로드：2017-08-23  조회수：

    A new in-vitro study UC Davis researchers reports that quaternary ammonium compounds (quats) used as antimicrobial agents in common household products inhibit mitochondria, the powerhouses of the cell, as well as estrogenic functions in cells. Their study is being published online in Environmental Health Perspectives.

    According to the researchers, toothpastes, mouthwashes, lozenges, nasal sprays, eye drops, shampoos, lotions, intravaginal spermicidal sponges, and household cleaners all contain quats.

    "Disinfectants that we are putting on and in our bodies, and using in our environment, have been shown to inhibit mitochondrial energy production and the cellular estrogen response," explained biochemist Gino Cortopassi, Ph.D., in the UC Davis School of Veterinary Medicine. "This raises concern because exposure to other mitochondrial-inhibiting drugs, such as rotenone and MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), is associated with increased risk for Parkinson's disease."

    The study focused on 1600 compounds and drugs associated with household and pharmaceutical products and examined a variety of aspects of mitochondrial functioning. The team discovered that that quats inhibited mitochondrial function and estrogen signaling.

    "Because exposure to quats is also interrupting the sex hormone estrogen response in cells, it could also potentially cause reproductive harm in animals or humans. Others have shown that quats cause reproductive toxicity in animals," added Dr. Cortopassi.

    While UC Davis scientists carried out an in vitro study, researchers at Virginia Tech several years ago reported that quat exposure through a laboratory disinfectant caused reproductive toxicity and reduced fertility in mice. They also recently demonstrated a link between quats and neural tube birth defects in both mice and rats.

    "Our study in cells provides a mechanism for their observations in laboratory animals," said Sandipan Datta, Ph.D., a postdoctoral scholar in Dr. Cortopassi's laboratory. "They demonstrated that quat exposure caused reproductive toxicity in both females and males. The antiestrogenic effects we see in cells could explain the female reproductive toxicity they observed, such as less estrus cycles and lower breeding rates."

    According to Dr. Cortopassi, the antiseptic triclosan and similar products were taken

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