Biopharmas Team Up with U.K.'s 100,000 Genomes Project

저자：   업로드：2015-08-07  조회수：

    Ten biopharma companies have joined together to create the Genomics Genomics Expert Network for Enterprises (GENE) Consortium, which will oversee a year-long trial designed to integrate industry expertise into the 100,000 Genomes Project—the U.K.’s effort to catapult itself to global leadership in genetic research into cancer and rare diseases.

    Through the GENE Consortium, the companies will work to discover how best to collaborate with clinicians and researchers in studying a selection of whole genome sequences across cancer and rare diseases. The consortium’s work is intended to accelerate the development of new diagnostics and treatments for patients, said Genomics England, the entity created by the U.K. Department of Health to run the 100,000 Genomes Project.

    The GENE Consortium’s 10 companies are: AbbVie, Alexion Pharmaceuticals, AstraZeneca, Biogen (which changed its name from Biogen Idec as of Monday), Dimension Therapeutics, GlaxoSmithKline, Helomics, Roche, Takeda, and UCB—whose participation is subject to contract negotiation and signature, Genomics England added.

    “We are particularly looking forward to contributing our expertise in understanding the role of biomarkers and personalized healthcare in the development of targeted medicines for patients,” Mene Pangalos, Ph.D., AstraZeneca’s evp of innovative medicines and early development, said in a statement.

    Helomics said in a company statement it will provide its PCAP^TM tumor profiling technology and diagnostics-focused expertise to the consortium. The company said its goal was to identify new biomarkers that could be used to develop more advanced cancer diagnostic tests and ultimately lead to new levels of personalized medicine.

    Genomics England also disclosed the areas where leading clinicians and scientists across the U.K. will explore within Genomics England’s Clinical Interpretation Partnership (GeCIP), formed to identify scientific findings and medical discoveries from the 100,000 Genomes dataset.

    As part of GeCIP, more than 28 teams or “domains” will be established for clinical and research experts in which to work. These include rare disease—a category it said will include cardiovascular, neurological, paediatrics domains—as well as cancers; pan-cancer analysis across many cancers; functional effects on gene expression, proteins and life-long DNA changes; electronic health records research; ethics, law and social science; health economics; validation and feedback.

    The 28 were selected from 88 applications to join GeCIP made by more than 2,000 researchers, clinicians, analysts, and trainees following a call to the research community in November 2014, Genomics England said.