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Skin Topical Preparation R&D

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Medicilon  can undertake the development process of various topical skin preparations, including ointments, creams, gels and other semi-solid preparations, as well as lotions, liniments and other solutions.  Medicilon fully complies with the requirements of China and global laws and regulations and guiding principles, as well as many years of development and research experience. 

The skin is the first line of physical defense in the human body. It is the largest organ of the human body which participates in various physiological functions . It consists of three easily distinguishable layers: the stratum corneum, the living epidermis and the dermis.

Skin diseases are complex and diverse, causing various degrees of disease which could burden on the entire life cycle of humans. Skin topical medicine is a kind of preparations that act on local or systemic treatment. The semi-solid topical preparations, which is a type of common preparation applied in skin medicine, are multiphase,. thermodynamically unstable and complex in composition,. It is classified as a complex preparation and has applications in the fields of innovative drugs, improved new drugs and generic drugs.

List of topical skin preparations

• Gel

• Ointment

  • • Solution type ointment
  • • Suspended ointment

• Cream

  • • Oil-in-water cream
  • • Water-in-oil cream

Medicilon's Services

Medicilon can undertake the development process of various topical skin preparations, including ointments, creams, gels and other semi-solid preparations, as well as lotions, liniments and other solutions. Medicilon fully complies with the requirements of China and global laws and regulations and guiding principles, as well as many years of development and research experience.

Medicilon has completed the development and application of a number of external preparation research projects for pharmaceutical companies and scientific research institutes.

Among them, Medicilon is well versed in the specificity of semi-solid preparations for skin topical in terms of technology development and review and approval, and comprehensively considers the product's prescription technology, quality control, packaging materials, commercial production and clinical application. Based on the analysis of the quality research profile, the key quality attributes (CQAs) of the products are used as the inspection indicators to conduct a sufficient screening study on the types and dosages of excipients.

Study on the quality of topical preparations:

• Formulation pH

• Water Activity

• Ratio of Undissolved Drug/Dissolved Drug

• Rheological Properties

  • • Characterization of Shear Stress and Shear Rate
  • • Yield Stress Value
  • • Linear Viscoelastic Response
  • • Viscosity Curve
  • • Linear Viscoelastic Range

• In Vitro Release Test/In Vitro Permeation Test) (IVRT/IVPT)

• Particle Size and Droplet Size Distribution Measurement

• Establishment of Microbiological Inspection Methods

  • • Establishment of Test Method for Burkholderia Cepacia

• Establishment of Antibacterial Efficacy Method

Image Analyzer for Particle Size Detection

Our platform is equipped with state-of-the-art and complete instruments to complete the various test items mentioned above:

Analysis equipment

• Brookfield Viscometer

• Image Analysis System for Measuring Droplet/Particle Size Distribution

• HAAKE MARS Rheometer

• Franz Diffusion Cell) (with Automatic Sampling System

• LC/MS System

Preparation Equipment

• Shearing Instrument

• Homogenizer

• Filling Equipment

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